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This can be a reactive, benign, or pathological state.

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The second is its inherent ability to absorb moisture.

Other soluble mediators of fibrosis include CTGF, platelet-derived growth factor (PDGF), and interleukin 10 (IL-10).

These initiate signal transduction pathways such as the AKT/m TOR pathways that ultimately lead to the proliferation and activation of fibroblasts, which deposit extracellular matrix into the surrounding connective tissue.

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Ebauchon is taken from the heart of the burl while plateaux is taken from the outer part of the burl.